Fons Verspaandonk studied with Herman Jeurissen at the Brabant Conservatory, where he graduated with honours.
He was a member of the Brabant Orchestra from 1995 to 1998, going on to play second horn in the Netherlands Radio Philharmonic Orchestra. He was appointed third horn with the Royal Concertgebouw Orchestra in January 2004. He has performed chamber music with Combattimento Consort Amsterdam. He has also played in the Ebony Band. Verspaandonk taught horn at the Fontys Conservatory in Tilburg from 2007 to 2011.
Verspaandonk is a member of the Farkas Quintet, with which he won the Jury Prize and the Audience Prize at the 2004 Almere National Chamber Music Competition.